Semax is a synthetic peptide developed in Russia as a derivative of ACTH (adrenocorticotropic hormone). It has been studied for its
neuroprotective, nootropic, and neurotrophic properties. Research suggests it may improve cognitive performance, enhance neuroplasticity,
and protect against ischemic and oxidative stress in the brain.
Key Benefits
• Cognitive Support: May enhance memory, learning, and focus.
• Neuroprotection: Protects neurons from ischemic and oxidative damage.
• Mood Regulation: Potential antidepressant and anxiolytic effects.
• Neurotrophic Effects: Stimulates BDNF (brain-derived neurotrophic factor) expression.
Clinical Findings
• Used in Russia for ischemic stroke recovery, cognitive decline, and optic nerve disorders.
• Studies report improvements in attention, memory, and recovery after brain injury.
• Shown to increase expression of neurotrophic factors in animal and human research.
Safety & Tolerability
• Generally well tolerated in studies.
• Mild side effects: transient headache, nasal irritation (intranasal route).
• Long-term safety data outside Russia is limited.
Dosing
• Common research administration: intranasal drops or sprays.
• Research protocols: 200–1200 mcg per day, divided into multiple doses.
• No standardized dosing in Western medicine — investigational use only.
For research and informational purposes only – not for medical use.




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